![]() Summary Second-line lipid-lowering agents include fibrates, bile acid resins, niacin, and cholesterol absorption inhibitors.Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile a. Zetia works to reduce the amount of cholesterol your body absorbs. Zetia is used to treat high cholesterol in people who cannot control their cholesterol levels by diet and exercise alone. Interactions FAQ What is Zetia? Zetia reduces the level of total cholesterol and LDL (bad) cholesterol in the blood.Binds to bile acids in the intestine, inhibiting its reabsorption into the blood. ![]() Inhibits absorption of dietary and biliary cholesterol in the small intestine. Decreases the adhesion of cholesterol in the arteries. Inhibits the biosynthesis of cholesterol in the liver. What is the mechanism of action of ezetimibe (Zetia)? a. This medicine was available only with your doctor's prescription. ![]() These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body. Ezetimibe is a cholesterol absorption inhibitor and atorvastatin is an HMG-CoA reductase inhibitor, or statin.
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